Des-γ-Carboxyprothrombin (DCP) and NX-DCP Expressions and Their Relationship with Clinicopathological Features in Hepatocellular Carcinoma
نویسندگان
چکیده
منابع مشابه
Des-γ-Carboxyprothrombin (DCP) and NX-DCP Expressions and Their Relationship with Clinicopathological Features in Hepatocellular Carcinoma
AIM Des-γ-carboxyprothrombin (DCP) has been used as a tumor marker for hepatocellular carcinoma (HCC). Recently the DCP/NX-DCP ratio, calculated by dividing DCP by NX-DCP, has been reported useful in detecting HCC. The purpose of this study is to clarify the significance of DCP and NX-DCP expression in HCC tissues. METHODS HCC and non-HCC tissue samples were obtained from 157 patients and wer...
متن کاملDes-γ-carboxy prothrombin (DCP) as a potential autologous growth factor for the development of hepatocellular carcinoma.
Des-γ-carboxy prothrombin (DCP) is a prothrombin precursor produced in hepatocellular carcinoma (HCC). Because of deficiency of vitamin K or γ-glutamyl carboxylase in HCC cells, the 10 glutamic acid (Glu) residues in prothrombin precursor did not completely carboxylate to γ-carboxylated glutamic acid (Gla) residues, leaving some Glu residues remained in N-terminal domain. These prothrombin prec...
متن کاملDes-gamma-carboxy prothrombin (DCP) antagonizes the effects of gefitinib on human hepatocellular carcinoma cells.
BACKGROUND/AIMS Des-gamma-carboxy prothrombin (DCP), an aberrant prothrombin produced by hepatocellular carcinoma (HCC) cells, is known as a marker for HCC. Recent studies indicated that high levels of DCP are associated with the malignant potential of HCC. In this study, we aimed to investigate the association of DCP with gefitinib treatment failure in HCC and whether DCP counteracts gefitinib...
متن کاملevolutionary origin and phylogenetic relationships among fusarium oxysporum f. sp. melonis isolates in iran and their relationship with nonpathogenic isolates
پژمردگی فوزاریومی خربزه و طالبی با عامل fusarium oxysporum f. sp. melonis از بیماری های مهم قارچی در مناطق رشد این گیاهان می باشد. جدایه های f. oxysporum از گیاهان و خاک ریزوسفر متعلق به پنج استان مهم تولیدکننده ی خربزه و طالبی جداسازی شد و بر پایه ی بیماری زایی در ارقام افتراقی، گروه های سازگاری رویشی (vegetative compatibility groups)، توالی سنجی ناحیه ی جداکننده ی بین ژنی دی اِن اِی ریبوزومی (n...
15 صفحه اولEffect of sorafenib on des-γ-carboxyprothrombin secretion by a human hepatocellular carcinoma cell line
Patients with hepatocellular carcinoma (HCC) who respond to sorafenib have been reported to exhibit an increase in the level of des-γ-carboxyprothrombin (DCP) in the blood, subsequent to the initiation of sorafenib treatment. In the present study, the levels of secretion of DCP and DCP with more γ-carboxyglutamic residues (NX-DCP) and the effects of hypoxic conditions were examined in 13 liver ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0118452